Recombinant Feline CD16 Protein

重组猫CD16蛋白 | 重组猫 CD16 蛋白

D 16 | CD 16a | CD16 | CD16a | CD16a antigen | CD16B | CD16b antigen | Fc fragment of IgG | Fc fragment of IgG low affinity IIIa receptor | Fc fragment of IgG low affinity IIIa receptor (CD16) | Fc fragment of IgG receptor IIIa | Fc fragment of IgG, low a

rp176261-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).

重组表达

21.9 kDa

C-His

29.6-46.9 kDa, under reducing conditions; 26.8-43.1 kDa, under non-reducing conditions

HEK293 Accession #: Q9N2I5 | HEK293

<1.0 EU/μg

猫(Feline)

21-207 aa

ADLSKAMVVLEPEWNRVLVSDGVILKCEGAYPPGDNSAQWWHNGSVIPHRAPSYSIEAARSEDSGEYKCQTGLSEASDPVQLEVHTGWLLLQAPRWVFQEGDTIQLRCHSWKNKTVQKVQYFQDGRGKMFFHKNSDFYIPKATSKHSGSYFCRGLIGNKNESSEAVNITVQGPPVPSTSTFLPHWYQHHHHHH

Yes

Yes