Recombinant Human PSMA/FOLH1 Protein

重组人PSMA/FOLH1蛋白 | 重组人谷氨酸羧肽酶2

Cell growth-inhibiting gene 27 protein | cell growth-inhibiting protein 27 | EC 3.4.17.21 | FGCP | folate hydrolase (prostate-specific membrane antigen) 1 | Folate hydrolase 1 | FOLH1 | FOLHNAALADase I | Folylpoly-gamma-glutamate carboxypeptidase | GCP2 |

rp176298-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Human prostate-specific membrane antigen (PSMA), a tumor marker in prostate cancer encoded by the FOLH1 gene, is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folypoly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I). In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. Inhibition of brain PSMA activity is considered to be a promising approach for the treatment of neurological disorders associated with glutamate excitotoxicity, such as stroke, chronic pain, and amyotrophic lateral sclerosis. Intestinal PSMA hydrolyzes folylpoly-gamma -glutamates, facilitating the uptake of folate. Post-translational: The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked.

Immobilized Recombinant Human PSMA/FOLH1 Protein (rp176298) at 1.0 μg/mL can bind Recombinant PSMA Antibody (Ab123637) with the EC50 of 7.9 ng/mL.

重组表达

80.3 kDa

N-His

91.7 kDa, under reducing conditions; 90.8 & 107.6 kDa, under non-reducing conditions.

CHO Accession #: Q04609 | CHO

<1.0 EU/μg

人(Human)

44-750 aa

MPLLLLLPLLWAGALAHHHHHHKSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA

Yes

Yes