Recombinant Human TRAIL R2/TNFRSF10B Protein

重组人TRAIL R2/TNFRSF10B蛋白 | 重组人TRAIL R2/TNFRSF10B蛋白

CD262 antigen | CD262 | death domain containing receptor for TRAIL/Apo-2L | Death receptor 5 | DR5 | DR5TRICK2B | Fas-like protein | KILLER/DR5 | KILLERapoptosis inducing protein TRICK2A/2B | TNF-related apoptosis-inducing ligand receptor 2 | TNFRSF10B |

rp176693-50μg

50μg

无动物源

≥95%(SDS-PAGE)

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Recombinant Human TRAIL R2/TNFRSF10B Protein (rp176693) inhibits Recombinant Human TRAIL mediated cytotoxicity using L-929 mouse fibroblast cells. The ED50 for this effect is 27.85 ng/mL. Immobilized Recombinant Human TRAIL R2/TNFRSF10B Protein (rp176693) at 5.0 μg/mL can bind Recombinant Human TRAIL Protein (rp169692) with the EC50 of 41.55 ng/mL.

重组表达

15.1 kDa

C-His

14.7&18.7 kDa, under reducing conditions; 13.7&17.5 kDa, under non-reducing conditions

HEK293 Accession #: O14763 | HEK293

<1.0 EU/μg

人(Human)

1-182 aa

MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKEHHHHHH

Yes

Yes