Recombinant Human Monoglyceride Lipase Protein

重组人Monoglyceride Lipase蛋白 | 重组人MGLL蛋白 | 重组人单酰甘油酯酶 | 重组人单酸甘油酯酶

HUK5 | HU-K5 | EC 3.1.1.23 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGLHUK5 | MGLL | Monoacylglycerol lipase | Monoglyceride Lipase

rp179784-10μg

10μg

无载体

≥85%(SDS-PAGE)

Monoacylglycerol lipase, also known as MAG lipase and MGLL, is a member of the serine hydrolase superfamily with the typical serine hydrolase catalytic triad. It converts monoacylglycerides to free fatty acids and glycerol. An important physiological process performed by MGLL is the breakdown of the endocannabinoid 2‑arachidonoylglycerol (2-AG) by hydrolysis to provide the arachidonic acid precursor for pro‑inflammatory eicosanoid synthesis. MGLL knock‑out mice exhibited enhanced learning and improved performance in novel object recognition due to the increased level of 2‑AG. In Alzheimer’s disease, inactivation of MGLL suppressed accumulation of β‑amyloid and reduced the expression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Measured by its ability to hydrolyze 4-Nitrophenyl butyrate (N138584). The specific activity is >15,000 pmol/min/μg.

重组表达

34.1 kDa

N-His

34.6 & 68.6 kDa, under reducing conditions

E. coli Accession #: Q99685 | E. coli

<1.0 EU/μg

人(Human)

2-303 aa

MHHHHHHPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP

No

Yes