Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein

重组人Aldo-keto Reductase 1C3/AKR1C3蛋白 | 重组人醛酮还原酶1C3蛋白

17-beta-hydroxysteroid dehydrogenase type 5 | 3-alpha-HSD type 2 | 3-alpha-hydroxysteroid dehydrogenase type 2 | AKR1C3 | Aldo-keto Reductase 1C3 | aldo-keto reductase family 1 member C3 | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid de

rp179839-10μg

10μg

无载体

≥95%(SDS-PAGE)

AKR1C3 is a member of the aldo-keto reductase (AKR) superfamily. It catalyzes oxidation/reduction reactions at the 3-alpha, 20-alpha, and 17-beta positions of steroids. It is also known as Prostaglandin F synthase as it reduces prostaglandin D2 to F2, and therefore may play a role in allergic conditions such as asthma. Elevated expression of AKR1C3 in endometrium that results in enhanced estrogen action may lead to endometrial cancer. It is also up‑regulated in squamous cell carcinoma of head and neck. AKR1C3 is found to be a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

Immobilized Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) at 1.0 μg/mL can bind Recombinant AKR1C3 Antibody (Ab087886) with the EC50 of 10.5 ng/mL.

重组表达

37.7 kDa

N-His

36.4 kDa, under reducing conditions; 36.7 kDa, under non-reducing conditions.

E. coli Accession #: P42330 | E. coli

<1.0 EU/μg

人(Human)

2-323 aa

MHHHHHHDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY

No

Yes