Recombinant Human Midkine Protein

重组人Midkine蛋白 | 重组人中期因子蛋白

Amphiregulin-associated protein | ARAP | MDK | MEK | Midgestation and kidney protein | midkine (neurite growth-promoting factor 2) | Midkine | MK1 | MKARAP | NEGF2 | NEGF2FLJ27379 | Neurite outgrowth-promoting factor 2 | Neurite outgrowth-promoting protei

rp179849-10μg

10μg

无载体

≥90%(SDS-PAGE)

Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase and the induction of cell proliferation. Midkine is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Midkine exhibited increased expression in the breast carcinomas but showed much lower expression in the normal breast tissue. Thus, it can be used as a breast carcinomas marker.

Determined by its ability to chemoattract human neutrophils using a concentration range of 1.0-10.0 ng/mL.

重组表达

14.2 kDa

N-His

16.8 kDa, under reducing conditions; 17.4 & 30.5 kDa, under non-reducing conditions.

E. coli Accession #: P21741 | E. coli

<1.0 EU/μg

人(Human)

23-143 aa

MHHHHHHKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD

No

Yes