Recombinant Human OX40/TNFRSF4 Protein

重组人OX40/TNFRSF4蛋白 | 重组人TNF受体超家族成员4蛋白

ACT-135 | ACT35 antigen | ACT35ATC35 antigen | CD134 antigen | CD134 | Ly-70 | OX40 cell surface antigen | OX40 homologue | OX40 | OX40L receptor | OX40lymphoid activation antigene ACT35 | TAX transcriptionally-activated glycoprotein 1 receptor | tax-tran

rp181285-10μg

10μg

无动物源

≥90%(SDS-PAGE)

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind BMS-986178 (anti-CD134) (Ab209739) with the EC50 of 38.0 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Ivuxolimab (anti-CD134) (Ab182815) with the EC50 of 32.7 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Tavolixizumab (anti-CD134) (Ab182830) with the EC50 of 41.2 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Cudarolimab (anti-CD134) (Ab182885) with the EC50 of 112.0 ng/mL.

重组表达

23.7 kDa

C-His

31.6- 49.3 kDa, under reducing conditions; 28.9-49.9 kDa, under non-reducing conditions

HEK293 Accession #: P43489 | HEK293

<1.0 EU/μg

人(Human)

1-216 aa

MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAHHHHHH

Yes

Yes