Recombinant Human CXCL3/GRO gamma Protein

重组人CXCL3/GRO gamma蛋白 | 重组人生长调节致癌基因γ蛋白

chemokine (C-X-C motif) ligand 3 | CINC-2 | CINC-2b | C-X-C motif chemokine 3 | CXCL3 | Dcip1 | Gm1960 | GRO gamma | GRO3 oncogene | GRO3 | GROG | GRO-gamma | GRO-gamma(1-73) | Growth-regulated protein gamma | Macrophage inflammatory protein 2-beta | mela

rp181572-10μg

10μg

无载体

≥95%(SDS-PAGE)

CXCL3, also known as Growth-regulated Oncogene gamma (GRO gamma), Macrophage Inflammatory Protein 2 beta (MIP-2beta), Dendritic Cell Inflammatory Protein 1 (DCIP-1), or Cytokine-induced Neutrophil Attractant 2 (CINC-2), is an 8 kDa pro-inflammatory member of the CXC subfamily of heparin-binding chemokines. Mature human CXCL3 (aa 35-107) shares 70% and 74% amino acid (aa) sequence identity with mouse and rat CXCL3, respectively. CXCL3 binds and activates CXCR2 to induce chemoattraction of CXCR2-expressing cells including neutrophils and endothelial cells. Additional N-terminal processing of mature CXCL3 by the removal of aa 35-38 increases its chemotactic activity by several fold. In addition to binding CXCR2, CXCL3 can also bind and be sequestered by the Duffy Antigen Receptor for Chemokines (DARC) decoy receptor. Post-translational: N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

重组表达

22.1 kDa

No tag

10.0 kDa, under reducing conditions; 10.6 kDa, under non-reducing conditions.

E. coli Accession #: P19876 | E. coli

<1.0 EU/μg

人(Human)

35-107 aa

GASVVTELRCQCLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN

No

Yes