Recombinant Human CD55/DAF Protein

重组人CD55/DAF蛋白 | 重组人衰变加速因子蛋白

CD55 antigen | CD55 molecule | decay accelerating factor for complement (Cromer blood group) | CD55 | CR | CRdecay accelerating factor for complement (CD55 | Cromer blood group system) | CROMDAFcomplement decay-accelerating factor | DAF | decay accelerati

rp181589-10μg

10μg

无动物源

≥95%(SDS-PAGE)

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. Post-translational: The Ser/Thr-rich domain is heavily O-glycosylated.

Immobilized Recombinant Human CD55 Protein (rp181589) at 2.0 μg/mL can bind CD55 Mouse mAb (Ab006577) with the EC50 of 555.0 ng/mL.​

重组表达

35.8 kDa

C-His

41.3-64.8 kDa, under reducing conditions; 38.1-55.0 kDa, under non-reducing conditions.

HEK293 Accession #: P08174 | HEK293

<1.0 EU/μg

人(Human)

1-353 aa

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSHHHHHH

Yes

Yes