Recombinant Human CD40/TNFRSF5 Protein

重组人CD40/TNFRSF5 蛋白 | 重组人CD40/TNFRSF5 蛋白 | 重组人 CD40/TNFRSF5 蛋白

B cell surface antigen CD40 | B-cell surface antigen CD40 | Bp50B cell-associated molecule | CD40 antigen | CD40 molecule, TNF receptor superfamily member 5 | CD40 type II isoform | CD40 | CD40L receptor | CDw40 | MGC9013 | nerve growth factor receptor-re

rp183577-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function: CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Recombinant Human CD40 Ligand Protein (rp169583) with the EC50 of 20.84 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind CD40 Mouse mAb (Ab094764) with the EC50 of 15.35 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Ravagalimab (anti-CD40) (Ab182860) with the EC50 of 11.32 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC50 of 4.37 ng/mL. Immobilized Recombinant Human CD40 Protein (rp183577) at 1.0 μg/mL can bind Giloralimab (anti-CD40) (Ab182875) with the EC50 of 25.5 ng/mL.

重组表达

20.0 kDa

C-His

28.7 kDa, under reducing conditions; 27.9 kDa, under non-reducing conditions

HEK293 Accession #: P25942 | HEK293

<1.0 EU/μg

人(Human)

1-193 aa

MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRHHHHHH

Yes

Yes