Recombinant Mouse CXCL1/KC Protein

重组小鼠CXCL1/KC蛋白

CINC1 | CINC-1 | CXCL1 | FSP | GRO alpha | GRO1 | GROa | KC | MGSA | MGSA-a | MGSA-alpha | NAP-3 | SCYB1

rp183578-10μg

10μg

无载体

≥95%(SDS-PAGE)

CXCL1, also known as KC, GRO alpha, and CINC-1, is an approximately 8 kDa proinflammatory chemokine that plays a key role in neutrophil migration and activation. Mature mouse CXCL1 shares 64% and 92% amino acid sequence identity with human and rat CXCL1, respectively. It is produced by many cell types in inflammatory sites and during chronic inflammatory diseases. CXCL1 can associate into bioactive dimers and primarily signals through CXCR2/IL-8 RB but can also bind with lower affinity to CXCR2/IL-8 RA. It induces neutrophil migration, extravasation, respiratory burst, and degranulation, and also induces T cells to produce proinflammatory IL-17. CXCL1 additionally binds to Syndecan-1 on epithelial cells, which acts as a sink for CXCL1 activity until Syndecan-1 cleavage by MMP-7. CXCL1 is up-regulated in spinal cord astrocytes by inflammatory stimuli or tumor cell injection, and it exacerbates pain sensation by potentiating excitatory NMDA neurotransmission. In the circulatory system, CXCL1 interacts with CXCR2 on endothelial cells to promote lymphatic tube formation and angiogenesis. It promotes the hypertrophic differentiation of chondrocytes, resulting in cartilage matrix deposition, calcification, and remodeling. It interacts with both CXCR1 and CXCR2 on adipose stromal cells and promotes their recruitment to prostate tumors in obese patients. It also binds CXCR2 on ovarian cancer cells, leading to cleavage of cell surface HB-EGF, transactivation of EGF R, and cell proliferation. Post-translational: The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

重组表达

8.3 kDa

No tag

10.1 kDa, under reducing conditions; 10.8 &14.8 kDa, under non-reducing conditions.

E. coli Accession #: P12850 | E. coli

<1.0 EU/μg

小鼠(Mouse)

20-96 aa

RLATGAPIANELRCQCLQTMAGIHLKNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK

No

Yes