Recombinant Human PTH Protein

重组人PTH蛋白 | 重组人甲状旁腺激素蛋白

Parathormone | Parathyrin | parathyroid hormone 1 | parathyroid hormone | PTH | PTH1

rp183592-10μg

10μg

无载体

≥95%(SDS-PAGE)

PTH (parathyroid hormone) is a critical hormone in the regulation of Ca++ homeostasis. The human PTH cDNA encodes 115 amino acids (aa) including a 25 aa signal sequence, a 6 aa propeptide, and an 84 aa mature hormone. Mature human PTH shares 70%, 73%, 88%, 87%, 86%, 86% and 85% aa identity with mouse, rat, canine, equine, bovine, porcine and feline PTH, respectively. Multiple N‑terminal peptides and C-terminal peptides derived from PTH occur naturally in the circulation. PTH aa 32-66, called PTH (1-34) since it represents the first 34 aa of the mature hormone, reproduces all the activity of the full length mature hormone and has been used therapeutically for treatment of osteoporosis. C-terminal peptides mainly oppose the activities of PTH (1-34) and are increased in renal failure. PTH expression is mainly restricted to the parathyroid gland, with minor amounts in the thymus. PTH secretion is enhanced by low Ca++ concentrations and inhibited by FGF-23. In normal human plasma, PTH correlates negatively with active Vitamin D and positively with ionized calcium. Human and other mammalian PTH will bind and stimulate human or rat PTH1R, activating adenylate cyclase and increasing cAMP production. PTH promotes secretion of TRANCE/RANKL and periostin through PTH1R binding on osteoblasts and/or bone marrow stromal cells. TRANCE/RANKL induces differentiation of osteoclasts, which in turn promote release of Ca++ from bone. PTH1R on osteocytes, however, allows PTH to promote bone formation and IGF-1 production. In renal epithelium, PTH promotes conversion of Vitamin D to its active form, lowers Ca++ excretion and increases phosphate excretion. PTH also increases hematopoietic stem cell proliferation and mobilization and induces arterial vasodilation by regulating Ca++ influx in PTH1R-expressing arterial smooth muscle.

Testing in progress

重组表达

9.42 kDa

No tag

11.4 kDa, under reducing conditions; 11.4 kDa, under non-reducing conditions.

E. coli Accession #: P01270 | E. coli

<1.0 EU/μg

人(Human)

32-115 aa

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

No

Yes