Recombinant Human S100A8 Protein

重组人S100A8蛋白 | 重组人S100A8蛋白

Calprotectin L1L subunit | Cystic fibrosis antigen (CFAG) | Leukocyte L1 complex light chain | Migration inhibitory factor-related protein 8 (MRP-8 | p8) | S100 calcium-binding protein A8 | Urinary stone protein band A | Calgranulin-A

rp183594-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein Function: S100A8 (also known as MRP8, Calgranulin A, and CP-10) and S100A9 (also known as MRP14 and Calgranulin B) are pro-inflammatory members of the S100 family of secreted calcium-binding proteins. They are up-regulated in neutrophils and monocytes at sites of inflammation (e.g. psoriasis, rheumatoid arthritis, cardiac ischemia) and are present at elevated concentrations in rheumatoid arthritis synovial fluid. The 10 kDa human S100A8 and 14 kDa S100A9 each contain two EF-hand calcium-binding motifs. Human S100A8 shares 57% and 61% amino acid (aa) sequence identity with mouse and rat S100A8, respectively. Human S100A9 shares 57% and 62% amino acid sequence identity with mouse and rat S100A9, respectively. S100A8 and S100A9 are noncovalent homodimers that can also noncovalently heterodimerize; in the presence of calcium and zinc, the homodimer and heterodimers will form tetramers. The heterodimer additionally binds and sequesters manganese, thereby restricting the growth of Mn-dependent bacteria. The S100A8/A9 heterodimer exhibits functions beyond those performed by the individual proteins. These include binding to fatty acids such as arachidonic acid and promoting astrocyte proliferation. S100A8, S100A9, and the heterodimer each promote neutrophil infiltration into sites of inflammation and inflammatory cytokine production by monocytes.

1. Immobilized Recombinant Human S100A8 Protein (rp183594) at 2.0 μg/mL can bind Recombinant Human S100A9 Protein (rp183637) with the EC50 of 135.5 ng/mL. 2. Immobilized Recombinant Human S100A9 Protein (rp183637) at 2.0 μg/mL can bind Recombinant Human S100A8 Protein (rp183594) with the EC50 of 194.6 ng/mL. 3. Immobilized Recombinant Human S100A8 Protein (rp183594) at 1.0 μg/mL can bind S100A8 Mouse mAb (Ab182004) with the EC50 of 18.63 ng/mL.

重组表达

11.7 kDa

C-His

11.7 kDa, under reducing conditions; 11.7 kDa, under non-reducing conditions

E. coli Accession #: P05109 | E. coli

<1.0 EU/μg

人(Human)

1-93 aa

MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETECPQYIRKKGADVWFKELDINTDGAVNFQEFLILVIKMGVAAHKKSHEESHKEHHHHHH

No

Yes