Recombinant Human FGF-18 Protein

重组人FGF-18蛋白 | 重组人成纤维生长因子18蛋白

FGF18 | FGF-18 | FGF-18ZFGF5 | fibroblast growth factor 18 | zFGF5

rp183678-10μg

10μg

无载体

≥95%(SDS-PAGE)

Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis. Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18. It is expressed in embryonic somites and the neural fold, adult lung, cerebellar and hippocampal neurons, hair follicle root sheath cells, and osteogenic mesenchymal cells. FGF-18 binds to FGF R2c, FGF R3c as well as the Golgi protein GLG1 and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes. FGF-18 is required for normal skeletal development. It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation.

Measured in a cell proliferation assay using BALB/3T3 mouse embryo fibroblasts cell. The ED50 for this effect is 6.91ng/mL.

重组表达

21.0 kDa

No tag

18.1 kDa, under reducing conditions; 18.1 kDa, under non-reducing conditions.

E. coli Accession #: O76093 | E. coli

<1.0 EU/μg

人(Human)

28-207 aa

EENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA

No

Yes