Recombinant Human PPM1A Protein

重组人PPM1A蛋白 | 重组人Mg2+/Mn2+依赖性蛋白磷酸酶1A

EC 3.1.3.16 | FLJ42306 | MGC9201 | MMPa-2 | MPPa-1 | phosphatase 2C alpha | PP2C alpha | Pp2c1 | PP2CA | PP2Calpha | PP2C-ALPHA | PPM1A | PPPM1A | protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | protein phosphatase 1A | protein

rp183695-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis. Post-translational: N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

Immobilized Recombinant Human PPM1A Protein (rp183695) at 1.0 μg/mL can bind PPM1A Antibody (Ab122785) with the EC50 of 21.2 ng/mL.

重组表达

36.7 kDa

C-His

39.1 kDa, under reducing conditions; 39.1 kDa, under non-reducing conditions.

E. coli Accession #: P35813 | E. coli

<1.0 EU/μg

人(Human)

1-324 aa

MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEGGSFNKKHHHHHH

No

Yes