Recombinant Human SULT2A1/ST2 Protein

重组人SULT2A1/ST2蛋白 | 重组人 SULT2A1/ST2 蛋白

Bile salt sulfotransferase 2A1 | Alcohol/hydroxysteroid sulfotransferase | Bile salt sulfotransferase | Dehydroepiandrosterone sulfotransferase | DHEA ST | Sult2a1 | DHEA sulfotransferase | DHEA-ST | DHEAS | EC 2.8.2.14 | Hst | hSTa | Hydroxysteroid sulfo

rp183708-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:14573603, PubMed:19589875, PubMed:21187059). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).

Testing in progress

重组表达

34.6 kDa

N-His

32.6 kDa, under reducing conditions; 31.9 kDa, under non-reducing conditions

E. coli Accession #: Q06520 | E. coli

<1.0 EU/μg

人(Human)

2-285 aa

MHHHHHHSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

No

Yes