Recombinant Human Prealbumin Protein

重组人Prealbumin蛋白 | 重组人过渡甲状腺素结合蛋白

Amyloid polyneuropathy | Amyloidosis I | ATTR | Carpal tunnel syndrome 1 | CTS | CTS1 | Dysprealbuminemic euthyroidal hyperthyroxinemia | Dystransthyretinemic hyperthyroxinemia | Epididymis luminal protein 111 | HEL111 | HsT2651 | PALB | Prealbumin | Prea

rp183710-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Prealbumin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. Prealbumin is a carrier protein which transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Transthyretin consists of a tetramer of identical subunits and is dominantly produced in the liver. Mutations in Prealbumin are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. Prealbumin is an indicator of protein-energy malnutrition since it has a circulating half life of 2 days and reacts swiftly to changes in nutritional status. Post-translational: Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.

Immobilized Recombinant Human Prealbumin Protein (rp183710) at 1.0 μg/mL can bind Recombinant Prealbumin Antibody (Ab008402) with the EC50 of 8.3 ng/mL.

重组表达

14.6 kDa

C-His

15.4 & 32.2 kDa, under reducing conditions; 15.4 & 32.2 kDa, under non-reducing conditions.

HEK293 Accession #: P02766 | HEK293

<1.0 EU/μg

人(Human)

1-147 aa

MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKEHHHHHH​

Yes

Yes