Recombinant Human Estrogen Receptor beta Protein

重组人Estrogen Receptor beta蛋白 | 重组人类雌激素受体β蛋白

Estrogen receptor 2 | estrogen receptor 2 (ER beta) | Estrogen receptor beta | estrogen receptor beta 4 | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | ER BETA | ER-beta | Erb | ESR B | ESR BETA | ESR2 | ESR2_HUMAN | ESRB | ESTRB | estrogen nucl

rp183732-1mg

1mg

无载体

≥95%(SDS-PAGE)

Purity:≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： ER beta/ESR2, a nuclear hormone receptor, exhibits estrogen-binding capabilities comparable to those of ESR1/ER-alpha and, in turn, triggers the expression of reporter genes harboring estrogen response elements (ERE) in an estrogen-dependent fashion. However, it is noteworthy that ER beta/ESR2 lacks intrinsic ligand binding ability and displays either no or minimal ERE binding activity, resulting in the attenuation or loss of ligand-dependent transactivation capacity. This dual nature, where it can bind estrogens but lacks the typical ligand-dependent activation potential, underscores its distinct regulatory role and highlights its contribution to the intricate network of estrogen-mediated signaling pathways.

重组表达

36.2 kDa

N-His

37.5 kDa, under reducing conditions

E. coli Accession #: Q92731 | E. coli

<1.0 EU/μg

人(Human)

2-318 aa

MHHHHHHDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPG

No

Yes