Recombinant Human PTEN Protein

重组人PTEN蛋白 | 重组人类 PTEN 蛋白

10q23del | BZS | DEC | GLM2 | MGC11227 | MHAM | MMAC1 | MMAC1 phosphatase and tensin homolog deleted on chromosome 10 | Mutated in multiple advanced cancers 1 | Phosphatase and tensin homolog | Phosphatase and tensin like protein | Phosphatidylinositol 3,

rp183747-1mg

1mg

无载体

≥90%(SDS-PAGE)

Purity: >90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), encodes a phosphatase that contains the catalytic signature motif (HCXXGXXRS/T) found in all members of the protein tyrosine phosphatase family. In vitro, the recombinant PTEN has both lipid phosphatase and protein phosphatase activities. Interestingly, accumulating evidence has shown that the tumor suppressor activity of PTEN relies on its ability to dephosphorylate phosphatidylinositol-triphosphate specifically at position 3 of the inositol ring. This activity reduces the levels of phosphatidylinositol-triphosphate which is specifically produced from phosphatidylinositol-diphosphate by PI 3-kinase upon activation by a variety of stimuli. Therefore, PTEN antagonizes PI 3-kinase-induced downstream signaling events and cellular processes including cell growth, apoptosis and cell motility. In vivo, the importance of PTEN catalytic activity in its tumor suppressor functions is underscored by the fact that the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity.

重组表达

47.9 kDa

C-His

52.8 kDa, under reducing conditions; 51.9 kDa, under non-reducing conditions

E. coli Accession #: P60484 | E. coli

<1.0 EU/μg

人(Human)

1-403 aa

MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKVHHHHHH

No

Yes