Recombinant Human MCAM/CD146 Protein

重组人MCAM/CD146蛋白 | 重组人黑色素瘤细胞黏附分子蛋白

CD146 antigen | CD146 | cell surface glycoprotein MUC18 | Cell surface glycoprotein P1H12 | L-Gicerin | MCAM | melanoma adhesion molecule | melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen | Melanoma-associated antigen A32 | Melanoma

rp183759-10μg

10μg

无动物源

≥95%(SDS-PAGE)

The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas.

Immobilized Recombinant Human MCAM/CD146 Protein (rp183759) at 1.0 μg/mL can bind Imaprelimab (anti-CD146) (Ab175560) with the EC50 of 30.9 ng/mL.

重组表达

60.5 kDa

C-His

85.8-108.9 kDa, under reducing conditions; 77.4-109.2 kDa, under non-reducing conditions.

CHO Accession #: P43121 | CHO

<1.0 EU/μg

人(Human)

1-559 aa

MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGHHHHHH

Yes

Yes