Recombinant Human IL-4R alpha Protein

重组人IL-4R alpha蛋白.

CD124 | IL 4R alpha | IL-4 receptor subunit alpha | IL-4-binding protein | IL-4R subunit alpha | IL-4R-alpha | IL-4RA | IL4-BP | Il4r | IL4R nirs variant 1 | IL4RA | IL4RA_HUMAN | Interleukin 4 receptor | Interleukin 4 receptor alpha chain | sIL4Ralpha/pr

rp184044-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. Post-translational: On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Measured by its ability to inhibit IL-4 induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 42.55 ng/mL in the presence of 20.0 ng/mL of Recombinant Human IL-4 Protein (rp147593).

重组表达

24.6 kDa

C-His

38.1-53.0 kDa, under reducing conditions; 38.1-53.0 kDa, under non-reducing conditions.

HEK293 Accession #: P24394 | HEK293

<1.0 EU/μg

人(Human)

1-232 aa

MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHHHHHHH

Yes

Yes