Recombinant Human Kallikrein 4/Prostase Protein

重组人Kallikrein 4/Prostase蛋白 | 重组人激肽释放酶4蛋白

AI2A1 | ARM1 | EC 3.4.21 | EC 3.4.21.- | EMSP | EMSP1 | EMSP1MGC116827 | Enamel matrix serine proteinase 1 | kallikrein 4 (prostase | Kallikrein 4 | kallikrein-4 | Kallikrein-like protein 1 | kallikrein-related peptidase 4 | KLK4 | KLK-L1MGC116828 | Prost

rp184059-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-2). The late protease is kallikrein 4 (KLK4). The principal functions of MMP-2 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of Amelogenesis Imperfecta Hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. Post-translational: N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.

重组表达

25.7 kDa

C-10His

29.7 kDa, under reducing conditions; 29.4 & 25.8 kDa, under non-reducing conditions

HEK293 Accession #: Q9Y5K2 | HEK293

<1.0 EU/μg

人(Human)

1-254 aa

MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQASHHHHHHHHHH

Yes

Yes