Recombinant Human p70 S6 Kinase Protein

重组人p70 S6 Kinase蛋白 | 重组人核糖体蛋白S6激酶β-1

EC 2.7.11 | EC 2.7.11.1 | p70 ribosomal S6 kinase alpha | p70 S6 kinase alpha | p70 S6 Kinase | p70 S6 kinase, alpha 1,70 kDa ribosomal protein S6 kinase 1 | p70 S6 kinase, alpha 2 | p70 S6KA | p70 S6K-alpha | p70(S6K)-alpha | p70-alpha | p70-S6K | P70S6K

rp184102-10μg

10μg

无载体

≥85%(SDS-PAGE)

p70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6K activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as at T389, a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1). Post-translational: Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism (PubMed:18925875, PubMed:19085255, PubMed:22017876, PubMed:23429703, PubMed:29236692).Activated by phosphorylation at Thr-252 by PDPK1 (PubMed:19864428, PubMed:9445476). Dephosphorylation by PPP1CC at Thr-412 in mitochondrion (PubMed:17936702).

重组表达

59.9 kDa

N-His

69.0 & 128.0 & 183.4 kDa, under reducing conditions; 65.8 & 70.3 & 120.2 & 183.4 kDa, under non-reducing conditions.

E. coli Accession #: P23443 | E. coli

<1.0 EU/μg

人(Human)

2-525 aa

MHHHHHHRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL

No

Yes