Recombinant Human SUMO2 Protein

重组人SUMO2蛋白

HSMT 3 | HSMT3 | MGC117191 | Sentrin 2 | Sentrin-2 | Sentrin2 | Small ubiquitin like modifier 2 | Small ubiquitin related modifier 2 | Small ubiquitin-related modifier 2 | SMT 3B | SMT3 homolog 2 | SMT3 suppressor of mif two 3 homolog 2 | SMT3 suppressor

rp184857-10μg

10μg

无载体

≥95%(SDS-PAGE)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX. Post-translational: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.

重组表达

11.4 kDa

N-His

15.4 kDa, under reducing conditions; 15.6 kDa, under non-reducing conditions.

E. coli Accession #: P61956 | E. coli

<1.0 EU/μg

人(Human)

2-93 aa

MHHHHHHADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG

No

Yes