Recombinant Human FOXM1 Protein

重组人FOXM1蛋白 | 重组人叉头盒M1蛋白

FKHL16 | Forkhead box M1 | Forkhead box protein M1 | forkhead like 16 | Forkhead-related protein FKHL16 | FOX M1 | Foxm1 | FOXM1_HUMAN | FOXM1B | Hepatocyte nuclear factor 3 forkhead homolog 11 | HFH-11 | HFH11 | HNF-3/fork-head homolog 11 | HNF3 | INS1 |

rp184895-10μg

10μg

无载体

≥90%(SDS-PAGE)

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). Post-translational: Phosphorylated in M (mitotic) phase (PubMed:17101782, PubMed:19160488, PubMed:30139873). Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782). Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1 (PubMed:19160488, PubMed:30139873). Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (PubMed:19160488).

重组表达

28.2 kDa

N-His

35.3 kDa, under reducing conditions; 35.3 kDa, under non-reducing conditions.

E. coli Accession #: Q08050 | E. coli

<1.0 EU/μg

人(Human)

2-250 aa

MHHHHHHKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAIN

No

Yes