Recombinant Human PSME1 Protein

重组人PSME1蛋白 | 重组人蛋白酶激活亚基1蛋白

11S regulator complex alpha subunit | 11S Regulator Complex Subunit alpha | 29-kD MCP activator subunit | IFI5111 | IFI5111MGC8628 | IGUP I-5111 | Interferon gamma up-regulated I-5111 protein | interferon-gamma IEF SSP 5111 | interferon-gamma-inducible pr

rp184933-10μg

10μg

无载体

≥90%(SDS-PAGE)

PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME1 gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring.

Immobilized Recombinant Human PSME1 Protein (rp184933) at 1.0 μg/mL can bind Recombinant PSME1 Antibody (Ab123720) with the EC50 of 9.1 ng/mL.

重组表达

28.6 kDa

No tag

29.5 kDa, under reducing conditions; 30.2 & 40.3 & 56.2 kDa, under non-reducing conditions.

E. coli Accession #: Q06323 | E. coli

<1.0 EU/μg

人(Human)

2-249 aa

AMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY

No

Yes