Recombinant Human SUMO1 Protein

重组人SUMO1蛋白

DAP1 | GAP modifying protein 1 | GAP-modifying protein 1 | GMP 1 | GMP1 | OFC10 | PIC 1 | PIC1 | SENP2 | Sentrin | Sentrin 1 | Small ubiquitin related modifier 1 | Small ubiquitin-like modifier 1 | Small ubiquitin-related modifier 1 | SMT3 | SMT3 homolog

rp184941-10μg

10μg

无载体

≥95%(SDS-PAGE)

Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2. Post-translational: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Polymeric SUMO1 chains undergo polyubiquitination by RNF4.

Testing in progress

重组表达

12.4 kDa

N-His

15.5 kDa, under reducing conditions; 15.5 kDa, under non-reducing conditions.

E. coli Accession #: P63165 | E. coli

<1.0 EU/μg

人(Human)

2-101 aa

MHHHHHHSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV​

No

Yes