Recombinant Rhesus Macaque IL-18/IL-1F4 Protein

重组猕猴IL-18/IL-1F4蛋白 | 重组猕猴白细胞介素18蛋白 | 重组猕猴白细胞介素-1家族成员4蛋白

Iboctadekin | IFN-gamma-inducing factor | IGIF | IGIFIL-1 gamma | IL18 | IL-18 | IL-18MGC12320 | IL-1F4 | IL1F4iboctadekin | IL-1g | Interferon gamma-inducing factor | interleukin 18 (interferon-gamma-inducing factor) | Interleukin-1 gamma | interleukin-1

rp186516-10μg

10μg

无载体

≥95%(SDS-PAGE)

Interleukin-18 (IL-18), also known as IL-1F4 and IFN-gamma inducing factor (IGIF), is a member of the IL-1 family of cytokines and is a key molecule in the innate immune response. Rhesus IL-18 is synthesized as a 24 kDa proprotein that contains a 36 amino acid (aa) propeptide and a 157 aa mature region. Under inflammatory conditions, the propeptide is cleaved by Caspase-1 in the cytoplasm to liberate the mature nonglycosylated 18 kDa monomeric IL-18. Mature rhesus IL-18 shares 96% aa sequence identity with human IL-18 and 60% - 76% with mouse, rat, canine, feline, and porcine IL-18. IL-18 is secreted by a variety of cell types including macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 interacts with the widely expressed IL-18 R alpha which then recruits the signaling subunit IL-18 R beta. The IL-1 family member IL-1F7 also binds to IL-18 R alpha but does not recruit IL-18 R beta or induce signaling. IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity. IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. IL-18 can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.

Testing in progress

重组表达

18.3 kDa

No tag

15.0 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions.

E. coli Accession #: Q9BGI5 | E. coli

<1.0 EU/μg

恒河猴(Rhesus monkey)

37-193 aa

YFGKLESKLSIIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIINMYKDSQPRGMAVAISVKCEKISTLSCENRIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLYKLILKKKDELGDRSIMFTVQNED

No

Yes