Recombinant Mouse IL-36Ra/IL-1F5 Protein

重组小鼠IL-36Ra/IL-1F5蛋白 | 重组人白介素36受体α蛋白

FIL1 delta | FIL1 | FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) | FIL1DIL-1 delta | IL1F5 (Canonical product IL-1F5a) | IL1F5 | IL-1HY1 | IL-1L1 | IL-1RP3 | IL36Ra | IL-36Ra | IL36RN | interleukin 1 family, member 5 (delta) | interleukin 1, delta | Interleuk

rp186533-10μg

10μg

无载体

≥95%(SDS-PAGE)

Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain. Post-translational: Removal of N-terminal methionine is necessary for full antagonistic activity.

Testing in progress

重组表达

16.9 kDa

No tag

15.5 kDa, under reducing conditions; 15.7 kDa, under non-reducing conditions.

E. coli Accession #: Q9QYY1 | E. coli

<1.0 EU/μg

小鼠(Mouse)

3-156 aa

VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD

No

Yes