Recombinant Human Topoisomerase II alpha/TOP2A Protein

重组人Topoisomerase II alpha/TOP2A蛋白 | 重组人DNA拓扑异构酶2-α蛋白 | 重组人Topoisomerase II alpha/TOP2A蛋白 | 重组人DNA拓扑异构酶IIα

alpha isozyme | ATP hydrolyzing DNA topoisomerase II alfa | DNA gyrase | DNA topoisomerase (ATP hydrolyzing) | DNA topoisomerase 2 alpha | DNA topoisomerase 2-alpha | DNA topoisomerase II | DNA topoisomerase II 170 kD | DNA topoisomerase II alpha isozyme

rp186556-10μg

10μg

无载体

≥90%(SDS-PAGE)

DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations. Post-translational: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.(Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1; leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks.SUMOylated.

重组表达

39.7 kDa

No tag

47.1 kDa, under reducing conditions; 47.1 kDa, under non-reducing conditions.

E. coli Accession #: P11388 | E. coli

<1.0 EU/μg

人(Human)

1174-1531 aa

GFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

No

Yes