Recombinant Human Sonic Hedgehog/Shh (C24II) Protein

重组人Sonic Hedgehog蛋白 | 重组人SHH蛋白 | 重组人 Sonic Hedgehog/Shh (C24II) 蛋白

HHG-1 | HLP3 | HPE3 | MCOPCB5 | MCOPCB5sonic hedgehog (Drosophila) homolog | Shh | ShhNC | SMMCI | HHG1 | SMMCIsonic hedgehog homolog (Drosophila) | sonic hedgehog homolog | sonic hedgehog protein | Sonic Hedgehog | TPT | TPTPS

rp188214-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein Function: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction.

Testing in progress

重组表达

19.7 kDa

No tag

19.3 kDa, under reducing conditions; 19.3 kDa, under non-reducing conditions

E. coli Accession #: Q15465 | E. coli

<1.0 EU/μg

人(Human)

24-197 (C24II) aa

IIGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGG

No

Yes