Recombinant Human CD8B Protein

重组人CD8B蛋白 | 重组人T细胞表面糖蛋白CD8β链蛋白

CD8b antigen | CD_antigen=CD8b | CD8 antigen 37 kDa chain | CD8 antigen beta polypeptide 1 | CD8 antigen beta polypeptide 1 (p37) | CD8 antigen, beta chain | CD8 antigen, beta polypeptide 1 | CD8 antigen, beta polypeptide 1 (p37) | CD8 beta | CD8b | CD8b

rp188222-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. Post-translational: Phosphorylated as a consequence of T-cell activation. Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.

Immobilized Recombinant Human CD8B Protein (rp188222) at 1.0 μg/mL can bind CD8 beta Antibody (Ab095390) with the EC50 of 874.3 ng/mL.

重组表达

44.3 kDa

C-hFc & His

45.0-55.0 kDa, under reducing conditions; 100.0-125.0 kDa, under non-reducing conditions.

HEK293 Accession #: P10966 | HEK293

<1.0 EU/μg

人(Human)

1-170 aa

MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPLEVLFQGPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH​

Yes

Yes