Recombinant Human Peroxiredoxin 1/PAG Protein

重组人Peroxiredoxin 1/PAG蛋白 | 重组人过氧化还原酶1蛋白

Heme binding 23 kDa protein | MSP23 | Natural killer cell-enhancing factor A | NKEF A | NKEF-A | NKEFA | OSF3 | Osteoblast specific factor 3 | PAG | Paga | PAGB | Peroxiredoxin 1 | Peroxiredoxin-1 | PRDX1 | PRDX1_HUMAN | Proliferation associated gene A |

rp188267-10μg

10μg

无载体

≥90%(SDS-PAGE)

Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker. Post-translational: Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.

Immobilized Recombinant Human Peroxiredoxin 1/PAG Protein (rp188267) at 1.0 μg/mL can bind Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) with the EC50 of 3.6 ng/mL.

重组表达

22.9 kDa

N-His

23.8 & 47.1 kDa, under reducing conditions; 23.0 & 25.7 & 42.9 kDa, under non-reducing conditions.

E. coli Accession #: Q06830 | E. coli

<1.0 EU/μg

人(Human)

2-199 aa

MHHHHHHSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK​

No

Yes