Recombinant Human Peroxiredoxin 6 Protein

重组人Peroxiredoxin 6蛋白 | 重组人过氧化物酶6蛋白 | 重组人过氧化还原酶6蛋白

1 Cys | 1 Cys peroxiredoxin | 1 Cys PRX | 1 cysPrx | 1-Cys peroxiredoxin | 1-Cys PRX | 24 kDa protein | 9430088D19Rik | AA690119 | Acidic calcium independent phospholipase A2 | Acidic calcium-independent phospholipase A2 | aiPLA2 | Antioxidant protein 2 |

rp188269-10μg

10μg

无载体

≥90%(SDS-PAGE)

PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities，which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft model. Post-translational: Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO2H) and sulfonic acid (Cys-SO3H) forms upon oxidative stress. Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (PubMed:26830860).

Testing in progress

重组表达

25.9 kDa

N-His

27.5 kDa, under reducing conditions; 26.5 & 27.5 & 46.2 & 50.2 kDa, under non-reducing conditions

E. coli Accession #: P30041 | E. coli

<1.0 EU/μg

人(Human)

2-224 aa

MHHHHHHPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

No

Yes