Recombinant Human PGD2 synthase/PTGDS Protein

重组人PGD2 synthase/PTGDS蛋白 | 重组人前列腺素D2合酶蛋白

Beta trace protein | Beta-trace protein | Cerebrin 28 | Cerebrin-28 | glutathione independent PGD synthase | Glutathione independent PGD synthetase | Glutathione-independent PGD synthase | L PGDS | Lipocalin type prostaglandin D synthase | Lipocalin-type

rp188273-10μg

10μg

无动物源

≥90%(SDS-PAGE)

PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Post-translational: N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.

重组表达

19.5 kDa

C-His

25.9-29.9 kDa, under reducing conditions; 23.7-28.2 kDa, under non-reducing conditions.

HEK293 Accession #: P41222 | HEK293

<1.0 EU/μg

人(Human)

1-190 aa

MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQHHHHHH

Yes

Yes