Recombinant Human CEACAM-19 Protein

重组人CEACAM-19蛋白 | 重组人癌胚蛋白相关细胞粘附分子19蛋白

carcinoembryonic antigen-related cell adhesion molecule 19 | CEACAM19 | CEACAM-19 | CEAL1

rp188289-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Carcinoembryonic antigen-related cell adhesion molecule-19 (CEACAM-19), also known as CEA-like gene 1 (CEAL1), is a member of the CEACAM subfamily of glycoproteins in the immunoglobulin (Ig) superfamily. Mature human CEACAM-19 consists of a 125 amino acid (aa) extracellular domain, a 21 aa helical transmembrane domain, and a 122 aa cytoplasmic domain. The extracellular domain contains an Ig-like domain as well as a glycosylation site, while the cytoplasmic domain is predicted to contain at least one immunoreceptor tyrosine-based activation motif (ITAM). The extracellular domain of human CEACAM-19 shows 71%, 72%, and 78% aa identity to mouse, rat, and bovine CEACAM-19. The CEACAM family of proteins are involved in numerous intercellular-adhesion and intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis. CEACAM-19 expression has been identified in a wide range of tissues including prostate, uterus, fetal brain, mammary and adrenal glands, skeletal muscle, small intestine, and kidney (1). Human CEACAM-19 has been found to be overexpressed in BT-474, BT20, and T47D breast cancer cell lines as well as LNCaP prostate cancer cells, suggesting a role in tumor progression and metastasis. The overexpression in breast cancer patients is associated with poor prognosis.

Testing in progress

重组表达

14.8 kDa

C-His

14.9- 23.2 kDa, under reducing conditions; 15.4-23.7 kDa, under non-reducing conditions.

HEK293 Accession #: Q7Z692 | HEK293

<1.0 EU/μg

人(Human)

1-157 aa

MEIPMGTQGCFSKSLLLSASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLFTYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGHHHHHH

Yes

Yes