Recombinant Human Desmocollin-3 Protein

重组人Desmocollin-3蛋白 | 重组人桥粒糖3蛋白 | 重组人桥粒芯胶黏蛋白3

Cadherin family member 3 | CDHF3 | CDHF3HT-CP | desmocollin 3 | Desmocollin3 | Desmocollin-3 | desmocollin-4 | DSC | DSC1 | DSC2 | DSC3 | DSC4 | DSC4desmocollin-3 | HT-CP

rp188311-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Desmocollin-3 is a 100 - 110 kDa type I transmembrane glycoprotein that belongs to the cadherin family of calcium dependent adhesion molecules. The human Desmocollin-3 is synthesized with a 108 amino acid (aa) propeptide. The mature protein consists of a 555 aa extracellular domain (ECD) that contains five cadherin-like domains, a 21 aa transmembrane segment, and a 185 aa cytoplasmic domain. Within the ECD, human Desmocollin-3 shares 78% aa sequence identity with mouse and rat Desmocollin-3. It shares 52% and 64% aa sequence identity with Desmocollin-1 and -2, respectively. A splice variant of human Desmocollin-3 has a truncated and substituted cytoplasmic domain. Desmocollin-3 is one of the principal components of desmosomes which form adhesive contacts between epithelial cells. It is expressed in the basal and suprabasal layers of stratified epithelia in many tissues. Desmocollin-1 and -2, by contrast, are preferentially localized in the more superficial layers. In mouse, Desmocollin-3 is expressed throughout embryogenesis and is required for non-desmosomal functions during early development. During apoptosis, both isoforms of Desmocollin-3 are proteolytically cleaved by caspases and metalloproteases. Desmocollin-3 can be upregulated or downregulated in carcinoma.

Testing in progress

重组表达

63.0 kDa

C-His

72.4 kDa, under reducing conditions; 76.0 kDa, under non-reducing conditions.

HEK293 Accession #: Q14574 | HEK293

<1.0 EU/μg

人(Human)

136-690 aa

RWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKHHHHHH

Yes

Yes