Recombinant Human Elongin-C Protein

重组人Elongin-C蛋白 | 重组人Elongin-C/ELOC蛋白

Elo C | EloC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin C | Elongin-C | ElonginC | RNA polymerase II transcription factor SIII subunit C | SIII | SIII p15 | TCEB 1 | Transcription elongation factor B (SIII) polypeptide | Transcription elongation fact

rp188313-10μg

10μg

无载体

≥90%(SDS-PAGE)

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Post-translational: Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome.

重组表达

13.3 kDa

N-His

12.3 kDa, under reducing conditions; 12.3 kDa, under non-reducing conditions.

E. coli Accession #: Q15369 | E. coli

<1.0 EU/μg

人(Human)

2-112 aa

MHHHHHHDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC​

No

Yes