Recombinant Human ENPP-7/Alk-SMase Protein

重组人ENPP-7/Alk-SMase蛋白

Alkaline sphingomyelin phosphodiesterase | alkaline sphingomyelinase | Alk-SMase | EC 3.1.4.12 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | E-NPP 7 | ENPP7 | ENPP-7 | Intestinal

rp188315-10μg

10μg

无动物源

≥95%(SDS-PAGE)

ENPP-7 (ectonucleotide pyrophosphatase/phosphodiesterase 7), also known as alkaline sphingomyelinase (alk-SMase) is expressed in the intestines and in human bile. It shares 30%36% homology with the members of the nucleotide pyrophosphatase/phosphodiesterese (NPP) family while sharing no similarities with neutral or acid SMase. Its main function is the digestion of dietary sphingomyelin by hydrolyzing sphingomyelin into ceramide and phosphorylcholine. ENPP-7 is reported to hydrolyse and inactivate platelet-activating factor (PAF) by a phospholipase C-type activity. Studies also show a decrease in ENPP-7 activity in human colorectal adenocarcinomas and human colorectal carcinomas, which indicate a potential role of ENPP-7 in human colon cancer. Post-translational: N-glycosylated; required for activity and transport to the plasma membrane.

Testing in progress

重组表达

48.3 kDa

C-His

56.6 kDa, under reducing conditions; 56.9 kDa, under non-reducing conditions.

HEK293 Accession #: Q6UWV6 | HEK293

<1.0 EU/μg

人(Human)

1-439 aa

MRGPAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTESALPPDGRPTLLPKGRSALPPSSHHHHHH

Yes

Yes