Recombinant Human DEP-1/CD148 Protein

重组人DEP-1/CD148蛋白 | 重组人受体型酪氨酸蛋白磷酸酶eta蛋白

CD148 antigen | CD148 | Density-enhanced phosphatase 1 | DEP1 | DEP-1 | DEP1EC 3.1.3.48 | HPTP eta | HPTPeta | HPTP-eta | human density enhanced phosphatase-1 | protein tyrosine phosphatase | Protein-tyrosine phosphatase eta | Protein-tyrosine phosphatase

rp188326-10μg

10μg

无载体

≥95%(SDS-PAGE)

Density Enhanced Protein Tyrosine Phosphatase (DEP-1), also known as CD148, HPTP-eta, and PTP receptor type J (PTPRJ), is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. A large (220 kilodalton) glycoprotein found at the cell surface, DEP-1 levels are increased with high cell density. DEP-1 phosphatase activity is enhanced by basement membrane proteins, suggesting it is involved in regulating cell adhesion and contact interactions. High levels of expression dampen PDGF, VEGF, and T-cell receptor responses. DEP-1 is widely expressed in tissues, particularly ones forming epithelioid monolayers. In the immune system, DEP-1 is found on all cell lineages and is highest on granulocytes. DEP-1 is the mutated gene in the Susceptibility to Colon Cancer locus Scc1, which is altered in many human colorectal adenomas. Gene knockout mice lacking DEP-1 die at midgestation due to failures in cardiovascular development. DEP-1 dephosphorylates a variety of proteins, including the HGF, PDGF, and VEGF receptors, and beta‑catenin. The recombinant protein is the intracellular region of DEP-1 containing the catalytic domain. Post-translational: N- and O-glycosylated.

Testing in progress

重组表达

40.5 kDa

N-His

36.9 kDa, under reducing conditions; 34.8 & 37.2 kDa, under non-reducing conditions.

E. coli Accession #: Q12913 | E. coli

<1.0 EU/μg

人(Human)

997-1337 aa

MHHHHHHRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA

No

Yes