Recombinant Human Cdc37 Protein

重组人Cdc37蛋白 | 重组人细胞分裂周期37, HSP90辅伴侣蛋白

CDC 37 | Cdc37 | CDC37 cell division cycle 37 homolog | CDC37 cell division cycle 37 S cerevisiae homolog | CDC37 cell division cycle 37, S cerevisiae, homolog of | Cdc37 homolog | CDC37 protein | CDC37_HUMAN | CDC37A | cell division cycle 37 | Cell divis

rp188343-10μg

10μg

无载体

≥90%(SDS-PAGE)

CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is thought to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified as Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age. Post-translational: Constitutively sumoylated by UBE2I.

Immobilized Recombinant Human Cdc37 Protein (rp188343) at 1.0 μg/mL can bind Recombinant Cdc37 Antibody (Ab095626) with the EC50 of 2.5 ng/mL.

重组表达

45.3 kDa

N-His

45.0 kDa, under reducing conditions

E. coli Accession #: Q16543 | E. coli

<1.0 EU/μg

人(Human)

2-378 aa

MHHHHHHVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV

No

Yes