Recombinant Human PCTAIRE1 Protein

重组人PCTAIRE1蛋白 | 重组人细胞周期蛋白依赖性激酶16

Cdk16 | CDK16_HUMAN | Cell division protein kinase 16 | Cyclin-dependent kinase 16 | PCTAIRE | PCTAIRE protein kinase 1 | PCTAIRE-motif protein kinase 1 | PCTAIRE1 | PCTGAIRE | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1

rp188345-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro) Post-translational: Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity (PubMed:22798068). Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity (By similarity). Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity (By similarity). Phosphorylation at Ser-153 inhibits kinase activity (PubMed:22798068).

重组表达

39.6 kDa

N-His

35.8 & 75.9 kDa, under reducing conditions; 35.8 & 75.9 kDa, under non-reducing conditions.

E. coli Accession #: Q00536 | E. coli

<1.0 EU/μg

人(Human)

158-496 aa

MHHHHHHGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF

No

Yes