Recombinant Human CSK Protein

重组人CSK蛋白 | 重组人酪氨酸蛋白激酶CSK蛋白

C SRC | C SRC kinase | C src Tyrosine Kinase | C-SRC kinase | c-src tyrosine kinase | CSK | Csk A | CSK_HUMAN | CYTOPLASMIC TYROSINE KINASE | EC 2.7.10.2 | MGC112926 | MGC117393 | MGC154049 | P60 Src | Protein tyrosine kinase CYL | Protein-tyrosine kinase

rp188360-10μg

10μg

无载体

≥90%(SDS-PAGE)

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. Post-translational: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.

Immobilized Recombinant Human CSK Protein (rp188360) at 1.0 μg/mL can bind Recombinant CSK Antibody (Ab097931) with the EC50 of 6.4 ng/mL.

重组表达

51.5 kDa

N-His

50.8 kDa, under reducing conditions; 50.8 kDa, under non-reducing conditions.

E. coli Accession #: P41240 | E. coli

<1.0 EU/μg

人(Human)

2-450 aa

MHHHHHHSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL

No

Yes