Recombinant Human DYNLL1/PIN Protein

重组人DYNLL1/PIN蛋白 | 重组人动力蛋白轻链1蛋白

Dynein Light Chain 1 Cytoplasmic | 8 kDa Dynein Light Chain | DLC8 | Dynein Light Chain LC8-Type 1 | Protein Inhibitor of Neuronal Nitric Oxide Synthase | PIN | DYNLL1 | DLC1 | DNCL1 | DNCLC1 | HDLC1

rp188378-10μg

10μg

无载体

≥95%(SDS-PAGE)

Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain. Post-translational: Phosphorylation at Ser-88 promotes recruitment to DNA double-strand breaks (DSBs) by TP53BP1 and ability to inhibit MRE11 (PubMed:37696958). Phosphorylation at Ser-88 appears to control the dimer-monomer transition (PubMed:15193260, PubMed:18650427). According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro (PubMed:15193260, PubMed:18650427).

Immobilized Recombinant Human DYNLL1/PIN Protein (rp188378) at 1.0 μg/mL can bind Recombinant DYNLL1/PIN Antibody (Ab100668) with the EC50 of 4.9 ng/mL.

重组表达

11.2 kDa

N-His

11.2 kDa, under reducing conditions; 11.2 kDa, under non-reducing conditions.

E. coli Accession #: P63167 | E. coli

<1.0 EU/μg

人(Human)

2-89 aa

MHHHHHHCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

No

Yes