Recombinant Human ENSA Protein

重组人ENSA蛋白 | 重组人α-内源性硫磺蛋白

Alpha endosulfine | Alpha-endosulfine | ARPP 19e | ARPP-19e | Endosulfine alpha | ENSA | ENSA_HUMAN

rp188386-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Post-translational: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA

Immobilized Recombinant Human ENSA Protein (rp188386) at 1.0 μg/mL can bind Recombinant ENSA Antibody (Ab101750) with the EC50 of 4.5 ng/mL.

重组表达

14.2 kDa

N-His

15.1 kDa, under reducing conditions; 15.1 kDa, under non-reducing conditions.

E. coli Accession #: O43768 | E. coli

<1.0 EU/μg

人(Human)

2-121 aa

MHHHHHHSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

No

Yes