Recombinant Human PSAP Protein

重组人PSAP蛋白 | 重组人鞘脂激活蛋白原蛋白 | 重组人前皂苷素蛋白

A1 activator | Cerebroside sulfate activator | Co-beta-glucosidase | Component C | CSAct | Dispersin | GLBA | Glucosylceramidase activator | Proactivator polypeptide | Proactivator polypeptide precursor | Prosaposin | Prosaposin (sphingolipid activator pr

rp188415-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. Post-translational: The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins. N-linked glycans show a high degree of microheterogeneity. The one residue extended Saposin-B-Val is only found in 5% of the chains.

Testing in progress

重组表达

57.3 kDa

C-His

54.8-71.8 kDa, under reducing conditions; 51.6-66.5 kDa, under non-reducing conditions.

HEK293 Accession #: P07602 | HEK293

<1.0 EU/μg

人(Human)

1-524 aa

MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWNHHHHHH

Yes

Yes