Recombinant Human Embigin/EMB Fc Chimera Protein

重组人Embigin/EMB蛋白 | 重组人恩比金蛋白

EMB | embigin homolog (mouse) | embigin homolog | Embigin | F9 | GP70 | H | MGC71745

rp188460-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Embigin (EMB) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF) proteins. It is a cell adhesion molecule that is preferentially expressed during mouse embryogenesis. Embigin, along with basigin and neuroplastin, form a small subgroup within the IgSF, with all members possessing a glutamate at the same position in the transmembrane domain. Mature, human Embigin is highly glycosylated and consists of an extracellular domain (ECD) wjth two Ig domains, a transmembrane region, and a short intracellular region. Within the ECD, human EMB shares 75% and 62% amino acid identity with mouse and rat EMB, respectively. Embigin is an accessory protein of monocarboxylic acid transporter, MCT2 which participates in transporting lactic acid between glial cells and neurons. Thus, it may be related to brain energy metabolism and has been investigated as a susceptible gene for schizophrenia. Embigin is highly expressed in early embryos of mice, and in the heart, lung, brain and other tissues of adult rats. Loss of embigin promotes proliferation, anchorage-independent growth, and migration ability of breast cancer cells.

重组表达

52.4 kDa

C-hFc

66.7-100.3 kDa, under reducing conditions; 154.5-220.4 kDa, under non-reducing conditions.

CHO Accession #: Q6PCB8 | CHO

<1.0 EU/μg

人(Human)

1-260 aa

MRALPGLLEARARTPRLLLLQCLLAAARPSSADGSAPDSPFTSPPLREEIMANNFSLESHNISLTEHSSMPVEKNITLERPSNVNLTCQFTTSGDLNAVNVTWKKDGEQLENNYLVSATGSTLYTQYRFTIINSKQMGSYSCFFREEKEQRGTFNFKVPELHGKNKPLISYVGDSTVLTCKCQNCFPLNWTWYSSNGSVKVPVGVQMNKYVINGTYANETKLKITQLLEEDGESYWCRALFQLGESEEHIELVVLSYLVP IEGRMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Yes

Yes