Recombinant Human PTPR sigma Protein

重组人PTPR Sigma蛋白 | 重组人蛋白酪氨酸磷酸酶受体S蛋白

EC 3.1.3.48 | protein tyrosine phosphatase PTPsigma | protein tyrosine phosphatase | PTP sigma | PTPR sigma | PTPRS | PTPSIGMA | receptor-type tyrosine-protein phosphatase S | Receptor-type tyrosine-protein phosphatase sigma | R-PTP-S | R-PTP-sigma | rece

rp188468-10μg

10μg

无载体

≥85%(SDS-PAGE)

Phosphatase Receptor-type sigma (PTPR sigma), also known as PTP sigma, is a 200 kDa type I transmembrane glycoprotein that is a member of the class 2A (LAR) subfamily of the protein tyrosine phosphatase (PTP) family. Human PTPR sigma cDNA encodes 1948 amino acids (aa) including a 29 aa signal sequence, a 1253 aa extracellular domain (ECD) with three C2-type Ig domains and eight Fibronectin (Fn) type III domains, a transmembrane domain, and a cytoplasmic region with two PTP domains. Multiple differentially expressed splice variants lack sections of the Ig and/or Fn domains and/or cytoplasmic juxtamembrane sequence. PKC activation in the cell promotes endoprotease cleavage of PTPR sigma, releasing the 140-160 kDa ECD. The human PTPR sigma ECD shares 93% aa sequence identity with the nearest isoform of mouse and rat PTPR sigma, 96% with bovine PTPR sigma, and 97% with porcine PTPR sigma. Activity of PTPR sigma can be inhibited by bisphosphonates. PTPR sigma is a receptor for several proteins, including neural chondroitin sulfate proteoglycans which inhibit nerve regeneration. It also binds and dephosphorylates targets such as N-Cadherin, E-Cadherin, EGF R and Ret. Through these interactions, PTPR sigma affects pituitary and neuroendocrine development, and axon growth and targeting. Mice deleted for PTPR sigma show pituitary, pancreatic, and gut abnormalities, mainly due to growth hormone insufficiency. They also show enhanced regeneration, but faulty targeting, of injured peripheral nerves. Head and neck squamous cell cancers frequently underexpress PTPR sigma. Since PTPR sigma inhibits EGF R signaling pathways, its underexpression can enhance tumor cell growth. Post-translational: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).

重组表达

65.7 kDa

N-GST & His

60.4 kDa, under reducing conditions; 60.4 kDa, under non-reducing conditions.

E. coli Accession #: Q13332-6 | E. coli

<1.0 EU/μg

人(Human)

1288-1615 aa

MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDGSTSGSGHHHHHHSAGENLYFQGPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGN

No

Yes