Recombinant Human Cyclin H/p34 Protein

重组人Cyclin H/p34/CCNH蛋白 | 重组人细胞周期蛋白H蛋白

6330408H09Rik | AI661354 | AV102684 | AW538719 | CAK | CAK complex subunit | Ccnh | CCNH_HUMAN | CDK activating kinase | CDK activating kinase complex subunit | Cyclin dependent kinase activating kinase | cyclin dependent kinase activating kinase complex

rp188483-10μg

10μg

无载体

≥90%(SDS-PAGE)

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Immobilized Recombinant Human Cyclin H/p34 Protein (rp188483) at 1.0 μg/mL can bind Recombinant Cyclin H/p34 Antibody (Ab098482) with the EC50 of 3.6 ng/mL

重组表达

38.5 kDa

N-His

36.9 kDa, under reducing conditions; 36.8 kDa, under non-reducing conditions.

E. coli Accession #: P51946 | E. coli

<1.0 EU/μg

人(Human)

2-323 aa

MHHHHHHYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL​

No

Yes