Recombinant Human CDA Protein

重组人CDA蛋白 | 重组人胞苷脱氨酶蛋白

CDD | Cytidine aminohydrolase | Cytidine deaminase | EC 3.5.4.5

rp188484-10μg

10μg

无载体

≥95%(SDS-PAGE)

Cytidine deaminase (CDA) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. CDA also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. CDA can form homotetramers and is generally expressed in granulocytes. Mutations in the CDA gene are linked to decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

重组表达

17.0 kDa

N-His

15.1 kDa, under reducing conditions; 15.1 kDa, under non-reducing conditions.

E. coli Accession #: P32320 | E. coli

<1.0 EU/μg

人(Human)

2-146 aa

No

Yes